Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity
نویسندگان
چکیده
منابع مشابه
Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity.
Brain glycogen stored in astrocytes provides lactate as an energy source to neurons through monocarboxylate transporters (MCTs) to maintain neuronal functions such as hippocampus-regulated memory formation. Although prolonged exhaustive exercise decreases brain glycogen, the role of this decrease and lactate transport in the exercising brain remains less clear. Because muscle glycogen fuels exe...
متن کاملLactate fuels the human brain during exercise.
The human brain releases a small amount of lactate at rest, and even an increase in arterial blood lactate during anesthesia does not provoke a net cerebral lactate uptake. However, during cerebral activation associated with exercise involving a marked increase in plasma lactate, the brain takes up lactate in proportion to the arterial concentration. Cerebral lactate uptake, together with gluco...
متن کاملLactate Fuels the Neonatal Brain
brain tissue. (2) Metabolic recovery pathways are fundamentally altered when lactate or hydroxybutyrate replaces glucose as the primary oxidative substrate. The implications of this study reach beyond enhancing our understanding of how the neonatal brain functions. While the observations that lactate can serve as a substrate for the neonatal brain confirms existing knowledge, the facts that it ...
متن کاملLactate and Glycogen Metabolism in the Lizard Dipsosaurus Dorsalis following Exhaustive Exercise
We evaluated the metabolic mechanisms by which the iguanid lizard Dipsosaurus dorsalis deals with the lactate which accumulates during vigorous exercise. Fasted, cannulated lizards were run for 5min on a treadmill at 40°C, which elevated whole-body lactate to 24mmoll~ and depleted hindlimb glycogen to 70% of resting levels. Oxygen consumption increased fivefold and respiratory exchange ratios a...
متن کاملLiver glycogen metabolism during and after prolonged endurance-type exercise.
Carbohydrate and fat are the main substrates utilized during prolonged endurance-type exercise. The relative contribution of each is determined primarily by the intensity and duration of exercise, along with individual training and nutritional status. During moderate- to high-intensity exercise, carbohydrate represents the main substrate source. Because endogenous carbohydrate stores (primarily...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1702739114